Resume de l’article : Découverte : un nouveau mécanisme élucidé dans la maladie de Huntington

Article’s title: « Découverte d’un nouveau mécanisme élucidé dans la maladie de Huntington »

The article explains that researchers have discovered a new mechanism in the brain involved in the progression of Huntington’s disease. In Huntington’s disease, there is an abnormal expansion of a repeated sequence of DNA (CAG) in the HTT gene. This results in the production of a mutant huntingtin protein that is toxic to the brain.

The researchers found that the mutant huntingtin protein causes a dysfunction of the nuclear pore complex (NPC), a structure located in the nuclear envelope that regulates the entry and exit of molecules from the cell nucleus. This NPC dysfunction leads to abnormal accumulation of proteins in the nucleus and impaired communication between the nucleus and the cytoplasm. These alterations contribute to the degeneration of neurons and the progression of Huntington’s disease.

Response: Researchers have discovered a new mechanism in the brain involved in the progression of Huntington’s disease, which involves a dysfunction of the nuclear pore complex caused by the mutant huntingtin protein. This dysfunction leads to abnormal accumulation of proteins in the nucleus and impaired communication between the nucleus and the cytoplasm, contributing to the degeneration of neurons and the progression of the disease.